Lurasidone (Latuda) and ziprasidone (Geodon) are both atypical antipsychotic medications used to treat schizophrenia and bipolar disorder. They are similar in efficacy, but lurasidone may be associated with less weight gain and somnolence:
- EfficacyIn a study of outpatients with schizophrenia, lurasidone and ziprasidone had similar efficacy, with an early onset of improvement in PANSS total score.
Weight gain
Lurasidone is associated with less weight gain than other antipsychotics. A study found that lurasidone was associated with less weight gain than quetiapine and olanzapine.
Somnolence
Lurasidone is associated with less somnolence than ziprasidone.
Side effects
Common side effects of ziprasidone include uncontrolled body movements, sleepiness, and nausea.
Lurasidone is also used to treat depressive episodes associated with bipolar I disorder.
Lurasidone (Latuda) | Ziprasidone (Geodon) | |
|---|---|---|
Conditions treated | Schizophrenia, depressive episodes associated with bipolar I disorder | Schizophrenia, bipolar I disorder |
Administration | Once daily tablet | Typically twice daily tablet, or injection given into muscles by a healthcare provider |
Common side effects | Sleepiness | Uncontrolled body movements, sleepiness, nausea |
This is for informational purposes only. For medical advice or diagnosis, consult a professional. Generative AI is experimental.
Latuda
has an average rating of 6.3 out of 10 from a total of 844 ratings on
Drugs.com. 51% of reviewers reported a positive effect, while 30%
reported a negative effect. Ziprasidone has an average rating of 5.7 out
of 10 from a total of 479 ratings on Drugs.com.
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